Water quality. Determination of the estrogenic potential of water and waste water - In vitro human cell-based reporter gene assay
Water quality. Determination of the estrogenic potential of water and waste water - In vitro human cell-based reporter gene assay
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1 Scope This document specifies a method for the determination of the estrogenic potential of water and waste water by means of a reporter gene assay utilizing stably transfected human cells. This reporter gene assay is based on the activation of the human estrogen receptor alpha. This method is applicable to:
— fresh water;
— waste water;
— aqueous extracts and leachates;
— eluates of sediments (fresh water);
— pore water;
— aqueous solutions of single substances or of chemical mixtures;
— drinking water;
— the limit of quantification ( LOQ ) of this method for the direct analysis of water samples is between 0,3 ng/l and 1 ng/l 17 β -estradiol equivalents (EEQ) based on the results of the international interlaboratory trial (see Annex F). The upper working range was evaluated [based on the results of the international interlaboratory trial (see Table F.3)] up to a level of 75 ng EEQ/l. Samples showing estrogenic p...
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