Containment enclosures — Part 1: Design principles
Containment enclosures — Part 1: Design principles
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ISO 10648-1:1997 – Containment enclosures - Part 1: Design principles provides internationally recognized guidelines for the design, mounting, and assembly of containment enclosures. Published by the International Organization for Standardization (ISO), this standard is essential for ensuring the protection of personnel and the environment during work with radioactive and/or toxic materials, and with processes requiring controlled or sterile atmospheres.
ISO 10648-1 focuses on three primary types of containment enclosures: glove boxes, tong boxes, and enclosures with remote manipulators, covering plastic, metal-framed, and hot-worked metal variants. The standard details selection criteria for materials, dimensional recommendations, and critical design considerations, supporting compliance with relevant safety regulations in nuclear, radiological, chemical, and biological laboratory settings.
Definitions and Scope Clarifies the terminology, applicable types of enclosures, and exclusions such as pressurized vessels, ventilated hoods, transport packaging, and reactor components.
Material Selection Highlights key properties of plastics, glass, and metal alloys. Considers factors like chemical resistance, transparency, mechanical strength, temperature range, fire load, and ease of decontamination.
Design Guidelines Sets out principles for constructing plastic, metal-framed, and hot-worked metal enclosures, including standard dimensions, typical configurations (like glove port spacing), and assembly methods.
Leak-tightness and Seals Introduces sealing techniques and types of seals suitable for ensuring leak-tight operation. Annexes provide indicative seal types and mounting recommendations.
Containment with Shielding Includes specific design principles for enclosures requiring additional shielding for handling beta, gamma, or neutron emitters.
Compliance and Safety Advises on the need for risk assessments throughout the lifecycle of the enclosure, from design and manufacturing to operation, maintenance, and decommissioning.
Nuclear and Radiological Laboratories Used extensively in environments handling radioactive materials, where robust containment and operator protection are paramount.
Chemical and Pharmaceutical Production Suitable for processes requiring the manipulation of toxic or sensitive substances under controlled atmospheres or sterile conditions.
Biotechnology and Research Facilities Enables safe work with infectious agents, recombinant materials, or operations needing strict isolation from the external environment.
Industrial Operations Applies to manufacturing and treatment processes where hazardous or contaminant control is necessary.
Shielded Applications Relevant for laboratories or facilities needing integrated or independent shielding to handle high-activity radioactive sources.
Implementing ISO 10648-1 ensures operational safety, regulatory compliance, and best practices in the design and use of containment enclosures. It supports the reliable containment of hazardous materials, minimizes contamination risks, and provides a basis for international harmonization in nuclear, laboratory, and industrial settings. By following the standard’s design guidelines, organizations can ensure effective environmental and personnel protection during critical containment applications.
For optimal performance and compliance, this standard should be used alongside related ISO standards relevant to specific containment and safety requirements.
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