ISO/TR 23463:2022 PDF

Nanotechnologies — Characterization of carbon nanotube and carbon nanofibre aerosols to be used in inhalation toxicity tests

Название (английский):

ISO/TR 23463:2022

Nanotechnologies — Characterization of carbon nanotube and carbon nanofibre aerosols to be used in inhalation toxicity tests

Статус документа:: Действующий
Формат:: Электронный (PDF)
Количество страниц:: 32
Дата публикации:: 18 мая 2022 г.
Издание:: ISO TR 23463 edition 1 version 1
ICS:: 07.120

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Описание (английский):

This document reviews characterization of CNT and CNF aerosols for inhalation exposure studies. The document also provides useful information on appropriate characterization of CNT and CNF, which is required to evaluate and understand the inhalation toxicity of CNT and CNF aerosols. This document neither provides guidance on aerosol characterization for other carbon nanomaterials, nor provides guidance for characterization of carbon nanotube and nanofibre aerosols in the workplace or ambient air.

Технические детали

Технический комитет: ISO/TC 229 - Nanotechnologies
SKU: ISO/TR 23463:2022

Abstract

Overview

ISO/TR 23463:2022 - Nanotechnologies - Characterization of carbon nanotube and carbon nanofibre aerosols to be used in inhalation toxicity tests - is a technical report that reviews best practices for characterizing carbon nanotube (CNT) and carbon nanofibre (CNF) aerosols used in inhalation exposure studies. The document focuses on parameters and measurement approaches needed to evaluate and interpret inhalation toxicity results. It does not provide guidance for workplace or ambient-air monitoring, nor for other carbon nanomaterials.

Key topics

The report organizes guidance around material- and aerosol-level characterization and highlights the physicochemical properties most relevant to toxicity:

Physicochemical parameters related to toxicity:
- Size, size distribution, length, width, aspect ratio and rigidity
- Aggregation/agglomeration state and morphology
- Aerodynamic properties for fiber deposition
- Specific surface area, crystalline structure and defects
- Surface chemistry, functionalization, surface charge, impurities
- Radical generation/scavenging potential and biodurability
Characterization stages:
- Characterize as-produced/supplied material prior to aerosol generation
- Characterize administered aerosol (sampling and measurement)
- Consider post-administration transformations
Measurement approaches:
- Direct (online) and indirect (off-line) methods for concentration and size metrics
- Metrics: mass, number, surface area, and volume concentrations
- Sampling considerations tailored to CNT/CNF morphology
Supporting content:
- Practical considerations for inhalation test design (chamber systems, exposure scenarios)
- Annexes summarizing physicochemical properties associated with biological activity and a list of aerosol monitoring instruments

Applications

ISO/TR 23463:2022 is intended to improve the scientific rigor and comparability of inhalation toxicity tests involving CNTs and CNFs. Practical uses include:

Designing and documenting inhalation toxicity studies (dose metrics, sampling)
Selecting appropriate characterization metrics and instruments for CNT/CNF aerosols
Interpreting toxicological endpoints in relation to material properties (e.g., long rigid fibers vs. short/tangled CNTs)
Supporting safer-by-design development, risk assessment, and regulatory submissions

Who should use this standard

Toxicologists and inhalation-study researchers
Nanomaterial characterization laboratories
Manufacturers and product developers working with CNTs/CNFs
Risk assessors and regulatory scientists evaluating inhalation hazards

Related standards

ISO 80004 (Nanotechnologies - Vocabulary) - referenced for terminology
ISO 10808 - nanoparticle characterization in inhalation chambers (complementary but distinct)
OECD inhalation toxicity test guidelines - related guidance for study performance

Keywords: ISO/TR 23463:2022, carbon nanotube aerosols, carbon nanofibre aerosols, CNT, CNF, inhalation toxicity, aerosol characterization, nanotechnologies, physicochemical properties, biodurability.

Overview

Key topics

The report organizes guidance around material- and aerosol-level characterization and highlights the physicochemical properties most relevant to toxicity:

Physicochemical parameters related to toxicity:
- Size, size distribution, length, width, aspect ratio and rigidity
- Aggregation/agglomeration state and morphology
- Aerodynamic properties for fiber deposition
- Specific surface area, crystalline structure and defects
- Surface chemistry, functionalization, surface charge, impurities
- Radical generation/scavenging potential and biodurability
Characterization stages:
- Characterize as-produced/supplied material prior to aerosol generation
- Characterize administered aerosol (sampling and measurement)
- Consider post-administration transformations
Measurement approaches:
- Direct (online) and indirect (off-line) methods for concentration and size metrics
- Metrics: mass, number, surface area, and volume concentrations
- Sampling considerations tailored to CNT/CNF morphology
Supporting content:
- Practical considerations for inhalation test design (chamber systems, exposure scenarios)
- Annexes summarizing physicochemical properties associated with biological activity and a list of aerosol monitoring instruments

Applications

ISO/TR 23463:2022 is intended to improve the scientific rigor and comparability of inhalation toxicity tests involving CNTs and CNFs. Practical uses include:

Designing and documenting inhalation toxicity studies (dose metrics, sampling)
Selecting appropriate characterization metrics and instruments for CNT/CNF aerosols
Interpreting toxicological endpoints in relation to material properties (e.g., long rigid fibers vs. short/tangled CNTs)
Supporting safer-by-design development, risk assessment, and regulatory submissions

Who should use this standard

Toxicologists and inhalation-study researchers
Nanomaterial characterization laboratories
Manufacturers and product developers working with CNTs/CNFs
Risk assessors and regulatory scientists evaluating inhalation hazards

Related standards

ISO 80004 (Nanotechnologies - Vocabulary) - referenced for terminology
ISO 10808 - nanoparticle characterization in inhalation chambers (complementary but distinct)
OECD inhalation toxicity test guidelines - related guidance for study performance

Keywords: ISO/TR 23463:2022, carbon nanotube aerosols, carbon nanofibre aerosols, CNT, CNF, inhalation toxicity, aerosol characterization, nanotechnologies, physicochemical properties, biodurability.

ISO/TR 23463:2022 PDF

Технические детали

Abstract

Overview

Key topics

Applications

Who should use this standard

Related standards

Похожие стандарты

Abstract

Overview

Key topics

Applications

Who should use this standard

Related standards

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